TD-0212 (TFA)

TD-0212 TFA is an orally active dual pharmacology angiotensin II type 1 receptor (AT1) antagonist and neprilysin (NEP) inhibitor, with a pKi of 8.9 for AT1 and a pIC50 of 9.2 for NEP[1].

Product Specifications

CAS Number

[1073549-11-7]

Product Name Alternative

8-Nitrotryptanthrin

UNSPSC

12352005

Target

Angiotensin Receptor; Neprilysin

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/td-0212-tfa.html

Concentration

10mM

Purity

98.44

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC(C(F)(F)F)=O.OC(C1=CC=CC=C1C2=CC=C(CN3C(CNC([C@H](CC(C)C)S)=O)=C(CC)N=C3OCC)C(F)=C2)=O

Molecular Formula

C30H35F4N3O6S

Molecular Weight

641.67

References & Citations

[1]McKinnell RM, et al. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI) . ACS Med Chem Lett. 2018 Dec 3;10 (1) :86-91.