EpoR (phospho Tyr368) rabbit pAb
This gene encodes the erythropoietin receptor which is a member of the Cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010],
Product Specifications
Background
Synonyms
EPOR; Erythropoietin receptor; EPO-R
Gene ID
2057
UniProt
P19235
Cellular Locus
Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]: Secreted. Secreted and located to the cell surface.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Epo-R around the phosphorylation site of Tyr368. AA range:341-390
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IF, ELISA
Validated Applications
WB,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
55kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES5137-1.pdf
Observed Molecular Weight
55 kD
Subcellular Location
Cell membrane; Single-pass type I membrane protein.; [Isoform EPOR-S]: Secreted . Secreted and located to the cell surface.
Other Product Names
EPOR; Erythropoietin receptor; EPO-R
Gene ID (Human)
2057
SwissProt (Human)
P19235
Available Sizes
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