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DGK-θ rabbit pAb

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008],

Product Specifications

Background

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]

Synonyms

DGKQ; DAGK4; Diacylglycerol kinase theta; DAG kinase theta; Diglyceride kinase theta; DGK-theta

Gene ID

1609

UniProt

P52824

Cellular Locus

Cytoplasm. Cytoplasm, cytosol. Cell membrane. Cell junction, synapse. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Nucleus matrix. Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189). Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189). Translocates to the nucleus in response to thrombin stimulation (Probable). Association with the nuclear matrix is regulated by nerve growth factor (By similarity)..

Host

Rabbit

Species Reactivity

Human,Rat,Mouse,

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human DGKQ. AA range:691-740

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB, IHC, IF, ELISA

Validated Applications

WB,IHC,IF,ELISA

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight

101kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES4961-1.pdf

Observed Molecular Weight

101 kD

Subcellular Location

Cytoplasm . Cytoplasm, cytosol . Cell membrane . Cell junction, synapse . Cytoplasm, cytoskeleton . Nucleus . Nucleus speckle . Nucleus matrix . Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189) . Translocation to the plasma membrane is dependent on G-protein coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189) . Translocates to the nucleus in response to thrombin stimulation (Probable) . Association with the nuclear matrix is regulated by nerve growth factor (By similarity) . .

Other Product Names

DGKQ; DAGK4; Diacylglycerol kinase theta; DAG kinase theta; Diglyceride kinase theta; DGK-theta

Gene ID (Human)

1609

SwissProt (Human)

P52824

Available Sizes

Curated Selection

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