FSI-TN42
FSI-TN42 (N42) is a selective, orally active and irreversible ALDH1A1 inhibitor with an IC50 of 23 nM. FSI-TN42 shows 800-fold more potent against ALDH1A1 than ALDH1A2 (IC50[1][2].
Product Specifications
CAS Number
[2445840-25-3]
Product Name Alternative
N42
UNSPSC
12352005
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/fsi-tn42.html
Purity
98.05
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(N1CCN(CC1)C2=CC=C(C(N3CCCCCC3)=C2)NC(C(Cl)Cl)=O)C4=CC=CN4C
Molecular Formula
C24H31Cl2N5O2
Molecular Weight
492.44
References & Citations
[1]Paik J, et al. Weight loss and metabolic effects of an ALDH1A1-specific inhibitor, FSI-TN42, in a diet induced mouse model of obesity. Int J Obes (Lond) . 2025 Mar;49 (3) :507-515. |[2]Haenisch M, et al. Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet-induced mouse model of obesity. Int J Obes (Lond) . 2021 Jul;45 (7) :1542-1552.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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