FSI-TN42

FSI-TN42 (N42) is a selective, orally active and irreversible ALDH1A1 inhibitor with an IC50 of 23 nM. FSI-TN42 shows 800-fold more potent against ALDH1A1 than ALDH1A2 (IC50[1][2].

Product Specifications

CAS Number

[2445840-25-3]

Product Name Alternative

N42

UNSPSC

12352005

Target

Aldehyde Dehydrogenase (ALDH)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/fsi-tn42.html

Purity

98.05

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(CC1)C2=CC=C(C(N3CCCCCC3)=C2)NC(C(Cl)Cl)=O)C4=CC=CN4C

Molecular Formula

C24H31Cl2N5O2

Molecular Weight

492.44

References & Citations

[1]Paik J, et al. Weight loss and metabolic effects of an ALDH1A1-specific inhibitor, FSI-TN42, in a diet induced mouse model of obesity. Int J Obes (Lond) . 2025 Mar;49 (3) :507-515. |[2]Haenisch M, et al. Investigation of an ALDH1A1-specific inhibitor for suppression of weight gain in a diet-induced mouse model of obesity. Int J Obes (Lond) . 2021 Jul;45 (7) :1542-1552.