SIK1 rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. enzyme regulation: Activated by phosphorylation on Thr-182 by STK11 in complex with STE20-related adapter-alpha (STRAD alpha) pseudo kinase and CAB39. function: Transient role during the earliest stages of myocardial cell differentiation and/or primitive chamber formation and may also be important for the earliest stages of skeletal muscle growth and/or differentiation. Potential role in G2/M cell cycle regulation. Inhibits CREB activity by phosphorylating and repressing the CREB-specific coactivators, CRTC1-3. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. AMPK subfamily. similarity: Contains 1 protein kinase domain. similarity: Contains 1 UBA domain. subcellular location: Translocates to the cytoplasm on phosphorylation where it binds binding to YWHAZ. subunit: Binds to and is activated by YWHAZ when phosphorylated on Thr-182.