What is the catalog number for Catenin-β (phospho Tyr489) rabbit pAb?

The catalog number for Catenin-β (phospho Tyr489) rabbit pAb is ES4891.

What sizes are available for Catenin-β (phospho Tyr489) rabbit pAb?

Catenin-β (phospho Tyr489) rabbit pAb is available in the following size(s): 50 µL, 100 µL.

How many pack sizes does Catenin-β (phospho Tyr489) rabbit pAb come in?

Catenin-β (phospho Tyr489) rabbit pAb is available in 2 different pack sizes.

Is Catenin-β (phospho Tyr489) rabbit pAb in stock?

Catenin-β (phospho Tyr489) rabbit pAb is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Catenin-β (phospho Tyr489) rabbit pAb?

Catenin-β (phospho Tyr489) rabbit pAb is manufactured by ELK.

What is the estimated delivery time for Catenin-β (phospho Tyr489) rabbit pAb?

Estimated delivery time for Catenin-β (phospho Tyr489) rabbit pAb is approximately 10 business day(s), depending on your location.

Catenin-β (phospho Tyr489) rabbit pAb

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016],

Product Specifications

Background

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) . AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

UniProt

P35222

Swiss Prot

P35222

Reactivity

Human; Mouse; Rat; Monkey

Immunogen

The antiserum was produced against synthesized peptide derived from human Catenin-beta around the phosphorylation site of Tyr489. AA range:455-504

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight

92kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

92kD

Fragment

IgG

Subcellular Location

Cytoplasm . Nucleus . Cytoplasm, cytoskeleton . Cell junction, adherens junction . Cell junction . Cell membrane . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cell junction, synapse . Cytoplasm, cytoskeleton, cilium basal body . Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity) . Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation) . Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of cent