Csk (phospho Ser364) rabbit pAb
Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. function: Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases. PTM: Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. similarity: Contains 1 protein kinase domain. similarity: Contains 1 SH2 domain. similarity: Contains 1 SH3 domain. subcellular location: Mainly cytoplasmic, also present in lipid rafts. subunit: Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1. tissue specificity: Expressed in lung and macrophages.
Product Specifications
Background
UniProt
P41240
Swiss Prot
P41240
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Csk around the phosphorylation site of Ser364. AA range:330-379
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
55kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
55kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .
Other Product Names
CSK; Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL
Gene ID (Human)
1445
Available Sizes
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