P38 rabbit pAb
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding d
Product Specifications
Background
Synonyms
Gene ID
1432
UniProt
Q16539
Cellular Locus
Cytoplasm. Nucleus.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Fish,Pig
Reactivity
Human; Mouse; Rat; Fish; Pig
Immunogen
The antiserum was produced against synthesized peptide derived from human p38 MAPK. AA range:147-196
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
IF, WB, IHC, ELISA
Validated Applications
IF,WB,IHC,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
38kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES4838-1.pdf
Observed Molecular Weight
38 kD
Subcellular Location
Cytoplasm . Nucleus .
Other Product Names
Gene ID (Human)
1432
SwissProt (Human)
Q16539
Available Sizes
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