COMT rabbit pAb
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008],
Product Specifications
Background
Product Name Alternative
COMT; Catechol O-methyltransferase
UniProt
P21964
Swiss Prot
P21964
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human COMT. AA range:61-110
Target
COMT
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
30kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
30kD
Fragment
IgG
Subcellular Location
[Isoform Soluble]: Cytoplasm .; [Isoform Membrane-bound]: Cell membrane ; Single-pass type II membrane protein ; Extracellular side .
Other Product Names
COMT; Catechol O-methyltransferase
Gene ID (Human)
1312
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
EDAR Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)
Rabbit Anti Human CFL1 Polyclonal Affinity Purified (PBS with 0.05% sodium azide and 50% glycerol, pH7.4) (IHC,ELISA)
Rgsl2h sgRNA CRISPR Lentivector (Rat) (Target 3)