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COL6A2 rabbit pAb

This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008],

Product Specifications

Background

This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Synonyms

COL6A2; Collagen alpha-2(VI) chain

Gene ID

1292

UniProt

P12110

Cellular Locus

Secreted, extracellular space, extracellular matrix. Membrane ; Peripheral membrane protein. Recruited on membranes by CSPG4.

Host

Rabbit

Species Reactivity

Human,Mouse,Monkey

Reactivity

Human; Mouse; Monkey

Immunogen

The antiserum was produced against synthesized peptide derived from human Collagen VI alpha2. AA range:691-740

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB, IHC, IF, ELISA

Validated Applications

WB,IHC,IF,ELISA

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight

109kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES4747-1.pdf

Observed Molecular Weight

109 kD

Subcellular Location

Secreted, extracellular space, extracellular matrix . Membrane ; Peripheral membrane protein . Recruited on membranes by CSPG4.

Other Product Names

COL6A2; Collagen alpha-2 (VI) chain

Gene ID (Human)

1292

SwissProt (Human)

P12110

Available Sizes

Curated Selection

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