Flumazenil acid
Flumazenil acid is a metabolite of Flumazenil[1]. Flumazenil is a GABAA receptor antagonist[2].
Product Specifications
CAS Number
84378-44-9
Product Name Alternative
Ro 15-3890
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite; GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/flumazenil-acid.html
Concentration
10mM
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C1=C(N(C2=CC=C(C=C2C3=O)F)C=N1)CN3C
Molecular Formula
C13H10FN3O3
Molecular Weight
275.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Kleingeist B, et al. Isolation and pharmacological characterization of microsomal human liver flumazenil carboxylesterase. J Pharm Pharm Sci. 1998 Jan-Apr;1 (1) :38-46.|[2]Mograbi KM, et al. Effects of GABAa receptor antagonists on motor behavior in pharmacological Parkinson's disease model in mice. Physiol Rep. 2017 Mar;5 (6) . pii: e13081.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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