ME3 rabbit pAb

Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP (+)-dependent isoform, a mitochondrial NADP (+)-dependent isoform, and a mitochondrial NAD (+)-dependent isoform. This gene encodes a mitochondrial NADP (+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008],