Grap rabbit pAb
This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. [provided by RefSeq, Jul 2012],
Product Specifications
Background
Synonyms
GRAP; GRB2-related adapter protein
Gene ID
10750
UniProt
Q13588
Cellular Locus
Membrane ; Peripheral membrane protein. Cell junction, synapse. Localizes at the presynaptic terminal..
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human GRAP. AA range:1-50
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
28kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES4549-1.pdf
Observed Molecular Weight
28 kD
Subcellular Location
Membrane ; Peripheral membrane protein . Cell junction, synapse . Localizes at the presynaptic terminal. .
Other Product Names
GRAP; GRB2-related adapter protein
Gene ID (Human)
10750
SwissProt (Human)
Q13588
Available Sizes
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