MLC-2 rabbit pAb

This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Dec 2014],

Product Specifications

Background

This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF) /Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]

UniProt

P19105/O14950/P24844

Swiss Prot

P19105/O14950/P24844

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human MLC-2. AA range:5-54

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000 , Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Stress fiber, cytosol, brush border, myosin complex, myosin II complex, Z disc, apical part of cell, extracellular exosome

Other Product Names

MYL12A; MLCB; MRLC3; RLC; Myosin regulatory light chain 12A; MLC-2B; Myosin RLC; Myosin regulatory light chain 2; nonsarcomeric; Myosin regulatory light chain MRLC3; MYL12B; MRLC2; MYLC2B; Myosin regulatory light chain 12B; MLC-2A; MLC-2; M