PDLIM5 (phospho Tyr251) rabbit pAb

This gene encodes a member of a family of proteins that possess a 100-amino acid PDZ domain at the N terminus and one to three LIM domains at the C-terminus. This family member functions as a scaffold protein that tethers protein kinases to the Z-disk in striated muscles. It is thought to function in cardiomyocyte expansion and in restraining postsynaptic growth of excitatory synapses. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012],

Product Specifications

Background

Product Name Alternative

PDLIM5; ENH; L9; PDZ and LIM domain protein 5; Enigma homolog; Enigma-like PDZ and LIM domains protein

UniProt

Q96HC4

Swiss Prot

Q96HC4

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human PDLIM5 (phospho Tyr251)

Target

PDLIM5

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

Buffer

-20°C/1 year

Molecular Weight

64kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

64kD

Fragment

IgG

Subcellular Location

Cell junction, synapse, postsynaptic density . Cell junction, synapse, presynapse . Cell junction, synapse, postsynapse . Cytoplasm, cytosol . Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons. .