DL-threo-3-Hydroxyaspartic acid

DL-threo-3-Hydroxyaspartic acid is a glutamate uptake inhibitor that can block glutamate transport in cannulated sprague dawley rat[1][2].

Product Specifications

CAS Number

[4294-45-5]

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

IGluR

Type

Peptides

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/dl-threo-3-hydroxyaspartic-acid.html

Purity

99.81

Solubility

H2O : 16.67 mg/mL (ultrasonic; adjust pH to 12 with 1 M NaOH)

Smiles

OC([C@@H](O)[C@H](N)C(O)=O)=O

Molecular Formula

C4H7NO5

Molecular Weight

149.10

Precautions

H302, H315, H319, H335

References & Citations

[1]A Klegeris, et al. Regulation of glutamate in cultures of human monocytic THP-1 and astrocytoma U-373 MG cells.J Neuroimmunol.1997 Sep;78 (1-2) :152-61.|[2]Jessica Darman, et al. Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity.J Neurosci. 2004 Aug 25;24 (34) :7566-75.