IL-1RII rabbit pAb
The protein encoded by this gene is a Cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a Cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012],
Product Specifications
Background
Product Name Alternative
UniProt
P27930
Swiss Prot
P27930
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human IL1R2. AA range:141-190
Target
IL-1RII
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
43kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
43kD
Fragment
IgG
Subcellular Location
[Isoform Short]: Secreted .; [Isoform Long]: Cell membrane; Single-pass type I membrane protein.
Other Product Names
Gene ID (Human)
7850
Available Sizes
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