NUMB rabbit pAb
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
Product Specifications
Background
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Product Name Alternative
NUMB; Protein numb homolog; h-Numb; Protein S171
UniProt
P49757
Swiss Prot
P49757
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the Internal region of human NUMB.
Target
NUMB
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IF; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IF/ICC 1:100-500; ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. .
Other Product Names
NUMB; Protein numb homolog; h-Numb; Protein S171
Gene ID (Human)
8650
Available Sizes
Frequently Asked Questions
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