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NUMB rabbit pAb

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],

Product Specifications

Background

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Product Name Alternative

NUMB; Protein numb homolog; h-Numb; Protein S171

UniProt

P49757

Swiss Prot

P49757

Reactivity

Human; Mouse; Rat

Immunogen

Synthesized peptide derived from the Internal region of human NUMB.

Target

NUMB

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IF; ELISA

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IF/ICC 1:100-500; ELISA 1:5000-20000

Buffer

-20°C/1 year

Molecular Weight

70kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

70kD

Fragment

IgG

Subcellular Location

Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to perinuclear endosomes in an AAK1-dependent manner. .

Other Product Names

NUMB; Protein numb homolog; h-Numb; Protein S171

Gene ID (Human)

8650

Available Sizes

Curated Selection

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