Apelin rabbit pAb

This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016],

Product Specifications

Background

Product Name Alternative

APLN; APEL; Apelin; APJ endogenous ligand

UniProt

Q9ULZ1

Swiss Prot

Q9ULZ1

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from the C-terminal region of human APLN. AA range:28-77

Target

Apelin

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

16kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

16kD

Fragment

IgG

Subcellular Location

Secreted . Secreted, extracellular space . Abundantly secreted in the colostrum. Lower level in milk. Decreases rapidly within several days after parturition in milk, but is still detectable even in commercial milk. .