CYP2A6/7/13 rabbit pAb
This gene, CYP2A6, encodes a member of the Cytochrome P450 superfamily of enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to hydroxylate coumarin, and also metabolizes nicotine, aflatoxin B1, nitrosamines, and some pharmaceuticals. Individuals with certain allelic variants are said to have a poor metabolizer phenotype, meaning they do not efficiently metabolize coumarin or nicotine. This gene is part of a large cluster of Cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. The gene was formerly referred to as CYP2A3; however, it has been renamed CYP2A6. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Product Name Alternative
UniProt
P11509/P20853/Q16696
Swiss Prot
P11509/P20853/Q16696
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from the Internal region of human CYP2A6/7/13.
Target
CYP2A6/7/13
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
56kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
56kD
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Other Product Names
Gene ID (Human)
1553
Available Sizes
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