Myosin VI rabbit pAb

Myosin VI (MYO6) Homo sapiens This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Golgi apparatus . Nucleus . Cytoplasm, perinuclear region . Membrane, clathrin-coated pit . Cytoplasmic vesicle, clathrin-coated vesicle . Cell projection, filopodium . Cell projection, ruffle membrane . Cell projection, microvillus . Cytoplasm, cytosol . Also present in endocyctic vesicles (PubMed:16507995) . Translocates from membrane ruffles, endocytic vesicles and cytoplasm to Golgi apparatus, perinuclear membrane and nucleus through induction by p53 and p53-induced DNA damage (PubMed:16507995) . Recruited into membrane ruffles from cell surface by EGF-stimulation (PubMed:9852149) . Colocalizes with DAB2 in clathrin-coated pits/vesicles (PubMed:11967127) . Colocalizes with OPTN at the Golgi complex and in vesicul