EEA1 rabbit pAb
Disease: Antibodies against EEA1 are found in sera from patients with subacute cutaneous lupus erythematosus and other autoimmune diseases. Domain: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate. function: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. similarity: Contains 1 C2H2-type zinc finger. similarity: Contains 1 FYVE-type zinc finger. subunit: Homodimer. Binds STX6. Binds RAB5A, RAB5B, RAB5C and RAB22A that have been activated by GTP-binding.
Product Specifications
Background
Synonyms
EEA1; ZFYVE2; Early endosome antigen 1; Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2
Gene ID
8411
UniProt
Q15075
Cellular Locus
Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human EEA1. AA range:205-254
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
162kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES3758-1.pdf
Observed Molecular Weight
162 kD
Subcellular Location
Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Other Product Names
EEA1; ZFYVE2; Early endosome antigen 1; Endosome-associated protein p162; Zinc finger FYVE domain-containing protein 2
Gene ID (Human)
8411
SwissProt (Human)
Q15075
Available Sizes
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