ZIS rabbit pAb

Domain: The RanBP2-type zinc fingers mediate binding to RNA. function: Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. PTM: Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR. sequence Caution: Intron retention. similarity: Belongs to the ZRANB2 family. similarity: Contains 2 RanBP2-type zinc fingers. subunit: Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of XE7 as well as with U2AF1 and CLK1.

Product Specifications

Background

Domain:The RanBP2-type zinc fingers mediate binding to RNA., function:Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection., PTM:Isoform 2 is phosphorylated on Ser-310 upon DNA damage, probably by ATM or ATR., sequence caution:Intron retention., similarity:Belongs to the ZRANB2 family., similarity:Contains 2 RanBP2-type zinc fingers., subunit:Interacts with the C-terminal half of SNRNP70, the Arg/Ser-rich domain of XE7 as well as with U2AF1 and CLK1.

Product Name Alternative

ZRANB2; ZIS; ZNF265; Zinc finger Ran-binding domain-containing protein 2; Zinc finger protein 265; Zinc finger; splicing

UniProt

O95218

Swiss Prot

O95218

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human ZNF265. AA range:106-155

Target

ZIS

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.