TNKS-2-IN-1

TNKS-2-IN-1 (Compound 13g) is a TNKS-2 inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM[1].

Product Specifications

CAS Number

[4765-59-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tnks-2-in-1.html

Purity

95.19

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N=C(C2=CC=C([N+]([O-])=O)C=C2)NC3=C1C=CC=C3

Molecular Formula

C14H9N3O3

Molecular Weight

267.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Nathubhai A, et al. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem. 2016 Aug 8;118:316-27.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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