TNKS-2-IN-1
TNKS-2-IN-1 (Compound 13g) is a TNKS-2 inhibitor. TNKS-2-IN-1 inhibits TNKS-1 and TNKS-2 with IC50s of 259 nM and 1100 nM[1].
Product Specifications
CAS Number
[4765-59-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tnks-2-in-1.html
Purity
95.19
Solubility
DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1N=C(C2=CC=C([N+]([O-])=O)C=C2)NC3=C1C=CC=C3
Molecular Formula
C14H9N3O3
Molecular Weight
267.24
Precautions
H302, H315, H319, H335
References & Citations
[1]Nathubhai A, et al. Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases. Eur J Med Chem. 2016 Aug 8;118:316-27.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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