UBE3C rabbit pAb
Function: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. miscellaneous: A cysteine residue is required for ubiquitin-thioester formation. pathway: Protein modification; protein ubiquitination. similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. similarity: Contains 1 IQ domain. subunit: Interacts with 26S proteasomes. Binds CAND2. tissue specificity: Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas.
Product Specifications
Background
Synonyms
UBE3C; KIAA0010; KIAA10; Ubiquitin-protein ligase E3C; HectH2
Gene ID
148581
UniProt
Q15386
Cellular Locus
Proteasome complex,intracellular,nucleus,cytoplasm,
Host
Rabbit
Species Reactivity
Human,Rat,Mouse,
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from the Internal region of human UBE3C.
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, ELISA
Validated Applications
WB,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
125kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES3667-1.pdf
Observed Molecular Weight
125 kD
Subcellular Location
Proteasome complex, intracellular, nucleus, cytoplasm
Other Product Names
UBE3C; KIAA0010; KIAA10; Ubiquitin-protein ligase E3C; HectH2
Gene ID (Human)
148581
SwissProt (Human)
Q15386
Available Sizes
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