TP53INP1 rabbit pAb

Function: In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. induction: By adriamycin, gamma irradiation and H (2)O (2), in a p53-dependent way. At lower levels by ultraviolet irradiation. subcellular location: Concentrated in PML/POD/ND10 nuclear bodies. subunit: Interacts with TP53 and HIPK2. tissue specificity: Ubiquitously expressed.

Product Specifications

Background

Function:In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis., induction:By adriamycin, gamma irradiation and H (2) O (2), in a p53-dependent way. At lower levels by ultraviolet irradiation., subcellular location:Concentrated in PML/POD/ND10 nuclear bodies., subunit:Interacts with TP53 and HIPK2., tissue specificity:Ubiquitously expressed.

UniProt

Q96A56

Swiss Prot

Q96A56

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human TP53INP1. AA range:171-220

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight

27kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

27kD

Fragment

IgG

Subcellular Location

Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.

Other Product Names

TP53INP1; P53DINP1; SIP; Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; p53-dependent damage-inducible nuclear protein 1; p53DINP1