Topo IIIβ-1 rabbit pAb
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013],
Product Specifications
Background
Synonyms
TOP3B; TOP3B1; DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1
Gene ID
8940
UniProt
O95985
Cellular Locus
Condensed chromosome,nucleus,cytosol,
Host
Rabbit
Species Reactivity
Human,Mouse
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human TOP3B. AA range:51-100
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
96kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES3627-1.pdf
Observed Molecular Weight
96 kD
Subcellular Location
Condensed chromosome, nucleus, cytosol
Other Product Names
TOP3B; TOP3B1; DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1
Gene ID (Human)
8940
SwissProt (Human)
O95985
Available Sizes
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