Topo IIIβ-1 rabbit pAb
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013],
Product Specifications
Background
UniProt
O95985
Swiss Prot
O95985
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human TOP3B. AA range:51-100
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
96kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
96kD
Fragment
IgG
Subcellular Location
Condensed chromosome, nucleus, cytosol
Other Product Names
TOP3B; TOP3B1; DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1
Gene ID (Human)
8940
Available Sizes
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