TNF-IP 8 rabbit pAb

Developmental stage: Expressed at high levels in the fetal liver, lung and kidney. function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. induction: By nuclear factor-KB (NF-KB) and TNF. Induction by TNF depends upon activation of NF-KB. similarity: Belongs to the TNFAIP8 family. tissue specificity: Expressed at high levels in the spleen, lymph node, thymus, thyroid, bone marrow and placenta. Expressed at high levels both in various tumor tissues, unstimulated and cytokine-activated cultured cells. Expressed at low levels in the spinal cord, ovary, lung, adrenal glands, heart, brain, testis and skeletal muscle.