TIS11B rabbit pAb

This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],

Product Specifications

Background

UniProt

Q07352

Swiss Prot

Q07352

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human TISB. AA range:58-107

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight

36kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

36kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm . Cytoplasmic granule . Cytoplasm, P-body . Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (By similarity) . Component of cytoplasmic stress granules (PubMed:15967811) . Localizes in processing bodies (PBs) (PubMed:17369404) . .

Other Product Names

ZFP36L1; BERG36; BRF1; ERF1; RNF162B; TIS11B; Zinc finger protein 36; C3H1 type-like 1; Butyrate response factor 1; EGF-response factor 1; ERF-1; Protein TIS11B