Synaptotagmin XI rabbit pAb

Synaptotagmin 11 (SYT11) Homo sapiens This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010],

Product Specifications

Background

Product Name Alternative

SYT11; KIAA0080; Synaptotagmin-11; Synaptotagmin XI; SytXI

UniProt

Q9BT88

Swiss Prot

Q9BT88

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human SYT11. AA range:181-230

Target

Synaptotagmin XI

Clonality

Polyclonal

Source

Rabbit

Applications

WB; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

48kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

48kD

Fragment

IgG

Subcellular Location

Cytoplasmic vesicle membrane ; Single-pass membrane protein . Perikaryon . Golgi apparatus, trans-Golgi network membrane ; Single-pass membrane protein . Recycling endosome membrane ; Single-pass membrane protein . Lysosome membrane ; Single-pass membrane protein . Cytoplasmic vesicle, phagosome . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, postsynaptic density . Recycling endosome membrane ; Single-pass membrane protein . Cytoplasmic vesicle, clathrin-coated vesicle membrane ; Single-pass membrane protein . Perikaryon . Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions. In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis (By similarity) . Found in the core of the