SnoN rabbit pAb
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Product Specifications
Background
UniProt
P12757
Swiss Prot
P12757
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human SKIL. AA range:616-665
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
77kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
77kD
Fragment
IgG
Subcellular Location
Acrosomal vesicle, nucleus, nucleoplasm, transcription factor complex, cytoplasm, PML body, transcriptional repressor complex, protein complex
Other Product Names
SKIL; SNO; Ski-like protein; Ski-related oncogene; Ski-related protein
Gene ID (Human)
6498
Available Sizes
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