SERCA1 rabbit pAb
This gene encodes one of the SERCA Ca (2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013],
Product Specifications
Background
Synonyms
Gene ID
487
UniProt
O14983
Cellular Locus
Endoplasmic reticulum membrane ; Multi-pass membrane protein. Sarcoplasmic reticulum membrane ; Multi-pass membrane protein.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat,Salamander,Pig
Reactivity
Human; Mouse; Rat; Salamander; Pig
Immunogen
The antiserum was produced against synthesized peptide derived from human ATP2A1. AA range:548-597
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB, IHC, IF, ELISA
Validated Applications
WB,IHC,IF,ELISA
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
100kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES3428-1.pdf
Observed Molecular Weight
100 kD
Subcellular Location
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Sarcoplasmic reticulum membrane ; Multi-pass membrane protein .
Other Product Names
Gene ID (Human)
487
SwissProt (Human)
O14983
Available Sizes
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