Nrf2 rabbit pAb

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015],

Product Specifications

Background

UniProt

Q16236

Swiss Prot

Q16236

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Nrf2. AA range:556-605

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight

75-100kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

75-100kD

Fragment

IgG

Subcellular Location

Cytoplasm, cytosol . Nucleus . Cytosolic under unstressed conditions: ubiquitinated and degraded by the BCR (KEAP1) E3 ubiquitin ligase complex (PubMed:15601839, PubMed:21196497) . Translocates into the nucleus upon induction by electrophilic agents that inactivate the BCR (KEAP1) E3 ubiquitin ligase complex (PubMed:21196497) . .

Other Product Names

NFE2L2; NRF2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor; erythroid derived 2, like 2