PKCβ inhibitor 1
Product Specifications
UNSPSC Description
PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKCβ2 relative to other PKC isozymes (PKCα, PKCγ, and PKCε)[1][2].
Target Antigen
Apoptosis; PKC
Type
Reference compound
Related Pathways
Apoptosis;Epigenetics;TGF-beta/Smad
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pkcβ-inhibitor-1.html
Smiles
O=C(C(C1=CN(CCCN2C=CN=C2)C3=C1C=CC=C3)=C4NC5=CC=CC=C5)NC4=O
Molecular Weight
411.46
References & Citations
[1]Tanaka M, et al. Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5171-4.|[2]Saba NS, et al. Protein kinase C-beta inhibition induces apoptosis and inhibits cell cycle progression in acquired immunodeficiency syndrome-related non-hodgkin lymphoma cells. J Investig Med. 2012 Jan;60(1):29-38.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13335/PKCβ-inhibitor-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13335/PKCβ-inhibitor-1-SDS-MedChemExpress.pdf
CAS Number
257879-35-9
Available Sizes
Curated Selection
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