Neurofibromin rabbit pAb
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008],
Product Specifications
Background
UniProt
P21359
Swiss Prot
P21359
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human NF1. AA range:1551-1600
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Molecular Weight
319kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
319kD
Fragment
IgG
Subcellular Location
Nucleus . Nucleus, nucleolus .
Other Product Names
NF1; Neurofibromin; Neurofibromatosis-related protein NF-1
Gene ID (Human)
4763
Available Sizes
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