MYSM1 rabbit pAb

Catalytic activity: Ubiquitin C-terminal thioester + H (2)O = ubiquitin + a thiol. Domain: Binds double-stranded DNA via the SANT domain. The SWIRM domain does not bind double-stranded DNA. function: Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the peptidase M67A family. MYSM1 subfamily. similarity: Contains 1 MPN (JAB/Mov34) domain. similarity: Contains 1 SANT domain. similarity: Contains 1 SWIRM domain. subunit: Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5. Binds histones.