Myotubularin rabbit pAb
This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008],
Product Specifications
Background
This gene encodes a dual-specificity phosphatase that acts on both phosphotyrosine and phosphoserine. It is required for muscle cell differentiation and mutations in this gene have been identified as being responsible for X-linked myotubular myopathy. [provided by RefSeq, Jul 2008]
Product Name Alternative
MTM1; CG2; Myotubularin
UniProt
Q13496
Swiss Prot
Q13496
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Myotubularin. AA range:241-290
Target
Myotubularin
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cell membrane; Peripheral membrane protein . Cell projection, filopodium . Cell projection, ruffle . Late endosome . Cytoplasm, myofibril, sarcomere . Localizes as a dense cytoplasmic network (PubMed:11001925) . Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles (PubMed:12118066) . Predominantly located in the cytoplasm following interaction with MTMR12 (PubMed:12847286) . Recruited to the late endosome following EGF stimulation (PubMed:14722070) . In skeletal muscles, co-localizes with MTMR12 in the sarcomere (By similarity) . .
Other Product Names
MTM1; CG2; Myotubularin
Gene ID (Human)
4534
Available Sizes
Curated Selection
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