MIF rabbit pAb

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

P14174

Swiss Prot

P14174

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human MIF. AA range:25-74

Clonality

Polyclonal

Source

Rabbit

Applications

IF; WB; IHC; ELISA

Concentration

1 mg/ml

Dilution

IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300

Molecular Weight

12kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

12kD

Fragment

IgG

Subcellular Location

Secreted . Cytoplasm . Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. .

Other Product Names

MIF; GLIF; MMIF; Macrophage migration inhibitory factor; MIF; Glycosylation-inhibiting factor; GIF; L-dopachrome isomerase; L-dopachrome tautomerase; Phenylpyruvate tautomerase