MBD3 rabbit pAb
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],
Product Specifications
Background
Product Name Alternative
MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3
UniProt
O95983
Swiss Prot
O95983
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MBD3. AA range:221-270
Target
MBD3
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
33kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
33kD
Fragment
IgG
Subcellular Location
Nucleus. Chromosome. Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.
Other Product Names
MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3
Gene ID (Human)
53615
Available Sizes
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