MAST205 rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. function: Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. PTM: Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination. similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. similarity: Contains 1 AGC-kinase C-terminal domain. similarity: Contains 1 PDZ (DHR) domain. similarity: Contains 1 protein kinase domain. subcellular location: Recruited to the sub-membranous area on interaction with PC-LKC. tissue specificity: Abundant in the testis.