LRRC41 rabbit pAb

Caution: It is uncertain whether Met-1 or Met-23 is the initiator. Domain: The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x (3)-C-x (3)-[AILV]. function: Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. pathway: Protein modification; protein ubiquitination. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. sequence Caution: Translation N-terminally extended. similarity: Contains 7 LRR (leucine-rich) repeats. subunit: Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS (LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2.