GRL-190-21
Product Specifications
UNSPSC Description
GRL-190-21 (compound 5e) is an inhibitor for SARS-Cov-2-Mpro with a Ki of 0.04 nM and exhibits antiviral activity in VeroE6 cells with EC50 of 0.26 μM. GRL-190-21 reduces the infectivity, replication, and cytopathic effect of SARS-CoV-2 without significant toxicity[1].
Target Antigen
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/grl-190-21.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C[C@@]2([H])C(NCCC2)=O)C#N)=O)[C@]3([H])[C@](C3(C)C)([H])C1)=O)C(F)(F)F
Molecular Weight
513.55
References & Citations
[1]Ghosh AK, et al., Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors. Eur J Med Chem. 2024 Feb 1;267:116132.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-162229/GRL-190-21-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-162229/
Clinical Information
No Development Reported
CAS Number
2755957-14-1
Curated Selection
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