GRL-190-21

GRL-190-21 (compound 5e) is an inhibitor for SARS-Cov-2-Mpro with a Ki of 0.04 nM and exhibits antiviral activity in VeroE6 cells with EC50 of 0.26 μM. GRL-190-21 reduces the infectivity, replication, and cytopathic effect of SARS-CoV-2 without significant toxicity[1].

Product Specifications

CAS Number

[2755957-14-1]

UNSPSC

12352005

Target

SARS-CoV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/grl-190-21.html

Solubility

10 mM in DMSO

Smiles

O=C(N[C@@H](C(C)(C)C)C(N1[C@H](C(N[C@@H](C[C@@]2([H])C(NCCC2)=O)C#N)=O)[C@]3([H])[C@](C3(C)C)([H])C1)=O)C(F)(F)F

Molecular Formula

C24H34F3N5O4

Molecular Weight

513.55

References & Citations

[1]Ghosh AK, et al., Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors. Eur J Med Chem. 2024 Feb 1;267:116132.