Integrin αV rabbit pAb
Integrin subunit alpha V (ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],
Product Specifications
Background
Product Name Alternative
ITGAV; MSK8; VNRA; Integrin alpha-V; Vitronectin receptor subunit alpha; CD antigen CD51
UniProt
P06756
Swiss Prot
P06756
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Integrin alphaV. AA range:755-804
Target
Integrin αV
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
135kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
135kD
Fragment
IgG
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion .
Other Product Names
ITGAV; MSK8; VNRA; Integrin alpha-V; Vitronectin receptor subunit alpha; CD antigen CD51
Gene ID (Human)
3685
Available Sizes
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