HPK1 rabbit pAb

Catalytic activity: ATP + a protein = ADP + a phosphoprotein. Cofactor: Magnesium. function: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. similarity: Contains 1 CNH domain. similarity: Contains 1 protein kinase domain. subunit: Interacts with MAP3K1. tissue specificity: Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.

Product Specifications

Background

Catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., function:May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation., similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily., similarity:Contains 1 CNH domain., similarity:Contains 1 protein kinase domain., subunit:Interacts with MAP3K1., tissue specificity:Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine.

Product Name Alternative

MAP4K1; HPK1; Mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1

UniProt

Q92918

Swiss Prot

Q92918

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human MEKKK 1. AA range:371-420

Target

HPK1

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

91kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

91kD

Fragment

IgG

Subcellular Location

Intracellular, cytoplasm, membrane

Other Product Names

MAP4K1; HPK1; Mitogen-activated protein kinase kinase kinase kinase 1; Hematopoietic progenitor kinase; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1