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HnRNP Q rabbit pAb

This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011],

Product Specifications

Background

This gene encodes a member of the cellular heterogeneous nuclear ribonucleoprotein (hnRNP) family. hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA (hnRNA) and regulate alternative splicing, polyadenylation, and other aspects of mRNA metabolism and transport. The encoded protein plays a role in multiple aspects of mRNA maturation and is associated with several multiprotein complexes including the apoB RNA editing-complex and survival of motor neurons (SMN) complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 20. [provided by RefSeq, Dec 2011]

Synonyms

SYNCRIP; HNRPQ; NSAP1; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding; cytoplasmic RNA-interacting protein

Gene ID

10492

UniProt

O60506

Cellular Locus

Cytoplasm. Microsome. Endoplasmic reticulum. Nucleus. The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity)..; [Isoform 1]: Nucleus, nucleoplasm. Expressed predominantly in the nucleoplasm..; [Isoform 2]: Nucleus, nucleoplasm. Expressed predominantly in the nucleoplasm..; [Isoform 3]: Nucleus, nucleoplasm. Expressed predominantly in the nucleoplasm..

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human hnRNP Q. AA range:236-285

Clonality

Polyclonal

Isotype

IgG

Source

Rabbit

Applications

WB, IHC, IF, ELISA

Validated Applications

WB,IHC,IF,ELISA

Stability

-20°C/1 year

Concentration

1 mg/mL

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

62kD

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES2554-1.pdf

Observed Molecular Weight

62 kD

Subcellular Location

Cytoplasm . Microsome . Endoplasmic reticulum . Nucleus . The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity) . Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity) . .; [Isoform 1]: Nucleus, nucleoplasm . Expressed predominantly in the nucleoplasm. .; [Isoform 2]: Nucleus, nucleoplasm . Expressed predominantly in the nucleoplasm. .; [Isoform 3]: Nucleus, nucleoplasm . Expressed predominantly in the nucleoplasm. .

Other Product Names

SYNCRIP; HNRPQ; NSAP1; Heterogeneous nuclear ribonucleoprotein Q; hnRNP Q; Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; NS1-associated protein 1; Synaptotagmin-binding; cytoplasmic RNA-interacting protein

Gene ID (Human)

10492

SwissProt (Human)

O60506

Available Sizes

Curated Selection

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