Histone deacetylase 7a rabbit pAb

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

Product Specifications

Background

Product Name Alternative

HDAC7; HDAC7A; Histone deacetylase 7; HD7; Histone deacetylase 7A; HD7a

UniProt

Q8WUI4

Swiss Prot

Q8WUI4

Reactivity

Human; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human HDAC7. AA range:901-950

Target

HDAC7

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Buffer

-20°C/1 year

Molecular Weight

105kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

105kD

Fragment

IgG

Subcellular Location

Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.