HGK rabbit pAb
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) Homo sapiens The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Product Specifications
Background
Product Name Alternative
UniProt
O95819
Swiss Prot
O95819
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human MEKKK 4. AA range:406-455
Target
HGK
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
142kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
142kD
Fragment
IgG
Subcellular Location
Cytoplasm .
Other Product Names
Gene ID (Human)
9448
Available Sizes
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