ATX inhibitor 5
ATX inhibitor 5 is a potent and orally active autotaxin (ATX) inhibitor, with an IC50 of 15.3 nM. ATX inhibitor 5 shows anti-hepatofibrosis effects and reduces CCl4-induced hepatic fibrosis level prominently[1].
Product Specifications
CAS Number
2402772-45-4
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/atx-inhibitor-5.html
Purity
99.20
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N/N=C/C1=CC=C(Cl)C=C1)N(C2)CCC3=C2C(NC4=CC=CC(C(F)(F)F)=C4)=NC=N3
Molecular Formula
C22H18ClF3N6O
Molecular Weight
474.87
References & Citations
[1]Jiang N, et al.Optimization and evaluation of novel tetrahydropyrido[4,3-d]pyrimidine derivatives as ATX inhibitors for cardiac and hepatic fibrosis.Eur J Med Chem. 2020 Feb 1;187:111904.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Autotaxin
Available Sizes
Frequently Asked Questions
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